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The Best Probiotics on Amazon

Updated By the HealthWorld editorial teamHow we pick

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Top picks at a glance

  1. 1
    Physician's Choice 60 Billion Probiotic

    Best multi-strain

    Physician's Choice 60 Billion Probiotic

    CFU 60 billion · Strains 10

  2. 2
    Garden of Life Dr. Formulated Probiotics Once Daily

    Best shelf-stable

    Garden of Life Dr. Formulated Probiotics Once Daily

    Strains Multi-strain · Storage Shelf-stable

  3. 3
    Culturelle Daily Probiotic

    Best single studied strain

    Culturelle Daily Probiotic

    CFU 10 billion · Strain LGG

Amazon's probiotics range from high-CFU, multi-strain capsules to single-strain formulas, and a bigger number isn't automatically better. Physician's Choice 60 Billion has long been one of Amazon's top-selling probiotics, so we compared it with Garden of Life Dr. Formulated and Culturelle by CFU, strains and storage.

Our picks

  1. Physician's Choice 60 Billion Probiotic

    #1Best multi-strain

    Physician's Choice 60 Billion Probiotic

    60 billion CFU from 10 strains plus a prebiotic fiber blend, in one delayed-release capsule a day. Long one of Amazon's top-selling probiotics.

    CFU 60 billionStrains 10eBay Full facts →
  2. Garden of Life Dr. Formulated Probiotics Once Daily

    #2Best shelf-stable

    Garden of Life Dr. Formulated Probiotics Once Daily

    A multi-strain, once-daily probiotic formulated by neurologist Dr. David Perlmutter, with versions for men, women and kids. Shelf-stable, so no refrigeration is needed.

    Strains Multi-strainStorage Shelf-stableeBay Full facts →
  3. Culturelle Daily Probiotic

    #3Best single studied strain

    Culturelle Daily Probiotic

    Built on Lactobacillus rhamnosus GG (LGG), one of the most researched probiotic strains in the world, at 10 billion CFU in one capsule a day.

    CFU 10 billionStrain LGGeBay Full facts →
Amazon's live top 100 in Probiotics

What to look for

Strains, not just CFU
A bigger CFU count isn't automatically better. Look for named strains, such as LGG in Culturelle, and favor products built on strains that have been studied.
CFU through the best-by date
Good labels state the CFU count guaranteed through the expiration date, not just at manufacture. Check the date when the bottle arrives.
Storage and shipping
Shelf-stable probiotics like Garden of Life Dr. Formulated handle delivery better. If a product says to refrigerate it, ordering online in hot weather is riskier.
The exact version
Brands sell several versions (men's, women's, extra-strength) on similar listings, and Garden of Life and Culturelle both have several formulas. Check the name, CFU and strains on the label before you buy.
Seller and safety
Buy from Amazon or the brand. Probiotics are generally well tolerated, but if you're immunocompromised, seriously ill or pregnant, ask your doctor first.

Frequently asked questions

What is the best-selling probiotic on Amazon?

Physician's Choice 60 Billion has long been one of the top-selling probiotics on Amazon. Rankings change often, so the order may be different when you look; choose by CFU and strains rather than rank.

Which probiotic on Amazon is best for women?

Garden of Life Dr. Formulated comes in a women's version, while Physician's Choice and Culturelle aren't sex-specific. Women's formulas usually differ in their strains, so compare the strain list on the label.

Is 60 billion CFU too much?

Not for most healthy adults, but it isn't necessarily better than 10 billion either. Some people notice gas or bloating in the first days with any probiotic; it usually settles, and if it doesn't, stop and talk to your doctor.

Do probiotics need to be refrigerated?

Only if the label says so. Shelf-stable ones, like Garden of Life Dr. Formulated, are made to stay viable at room temperature until the best-by date. Keep any probiotic away from heat and moisture.

Can I take a probiotic every day?

Yes, most are designed for daily use, and their effects generally last only as long as you keep taking them. Give one a few weeks before judging it.

Sources