The Best Protein Powders for Weight Loss
Updated By the HealthWorld editorial teamHow we pick
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Top picks at a glance
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For weight loss, look for a powder with a lot of protein for few calories, so it supports fullness and helps you keep muscle while you eat less. Isopure Zero Carb is our top pick, with 25 g of protein and 0 g of carbs and sugar per serving. Myprotein Impact Whey is the budget pick at about 120 calories a scoop, and Orgain + 50 Superfoods adds 8 g of fiber for plant-based diets.
Our picks

#1Best overall
Isopure Zero Carb Whey Isolate
100% whey protein isolate with 25 g of protein and 0 g of carbs and sugar per serving, so nearly every calorie is protein.

#2Best budget pick
Myprotein Impact Whey Protein
22 g of protein for about 120 calories per scoop, and among the lowest cost per serving of the big brands.

#3Best if you dislike creamy shakes
Myprotein Clear Whey Isolate
20 g of protein from whey isolate in a light, juice-like drink that's low in sugar and fat.

#4Best plant-based, high fiber
Orgain Organic Protein + 50 Superfoods
21 g of plant protein, 8 g of fiber and 1 g of sugar for 160 calories. USDA Organic and vegan.

#5Best for training while dieting
Dymatize ISO100 Hydrolyzed
Hydrolyzed whey protein isolate with 25 g of protein per serving and very little fat or sugar.
What to look for
- Protein per calorie
- Divide grams of protein by calories. Isolates and lean wheys reach 20 g or more of protein for well under 150 calories; mass gainers go the other way and don't belong in a weight-loss plan.
- Sugar and carbs
- Check sugar per serving on the label. Some flavored powders and ready-to-drink shakes add more sugar than you'd expect.
- Fiber
- Fiber adds to fullness. Plant powders with added fiber, like Orgain + 50 Superfoods, can make a shake feel more like a snack.
- A taste you'll stick with
- A diet works when you can keep it up. Pick a flavor and texture you like, or an unflavored powder you can mix into yogurt, oats or coffee.
Frequently asked questions
Is whey or plant protein better for weight loss?
Neither has a clear advantage. What matters is total calories and getting enough protein to stay full and keep muscle. Compare calories, sugar and protein per serving, and choose the one you digest well.
Can I replace a meal with a protein shake?
A protein shake alone isn't a full meal: it lacks the fiber, fats and many nutrients of real food. Blending powder with fruit, oats or nut butter makes a more balanced shake. Ask a dietitian before replacing meals regularly.
How many protein shakes a day for weight loss?
One or two a day is common, to help you reach your daily protein target. More than that usually means you're replacing food you'd be better off eating.
Will protein powder make me gain weight?
Protein powder has calories like any food. Used to replace a higher-calorie snack, it can support weight loss; added on top of your usual diet, it adds calories.
Sources
- Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements
- Dietary Supplements — U.S. Food & Drug Administration